Vitamin D is necessary for strong bones and muscles. Without Vitamin D, our bodies cannot effectively absorb calcium, which is essential to good bone health. Children who lack Vitamin D develop a condition called rickets, which causes bone weakness, bowed legs, and other skeletal deformities, such as stooped posture.
What are the roles of vitamin C and D in bone development?
What does vitamin D do in bone remodeling?
Vitamin D stimulates osteoclastogenesis acting through its nuclear receptor (VDR) in immature osteoblast/stromal cells. This mobilization of calcium stores does not occur in a random manner, with bone preferentially removed from cancellous bone.
What role does calcium play in bone remodeling?
Calcium is one of the most abundant elements in the human body and is a major component of the mineralized tissues where more than 99% of total body calcium is contained. It plays a key role in skeleton mineralization and is required for normal growth, development, and bone strength .
What is the main function of vitamin D and bone growth is two?
Vitamin D is both a nutrient we eat and a hormone our bodies make. It is a fat-soluble vitamin that has long been known to help the body absorb and retain calcium and phosphorus; both are critical for building bone.
What micronutrients are needed for bone remodeling?
The most important and studied micronutrients in the prevention and treatment of osteoporosis are Ca and vitamin D. However, other minerals and vitamins (e.g., P, Mg, zinc, selenium, copper, vitamins C, K, A, B) are also involved in bone formation.